COMPOSITION COMPRISING A VITAMIN D DERIVATIVE FOR THE LOCAL TREATMENT OF BONE FRACTURES

摘要

A method for the treatment and promotion of healing of bone fractures and osteotomies in warm-blooded animals including humans, which comprises local application to the site of the fracture or osteotomy of a therapeutically effective amount of 24,25(OH)2D3 dissolved or dispersed in a suitable physiologically compatible carrier. There are also provided, for use in the above method, compositions comprising from 0.002 to 0.2% by weight of 24,25(OH)2D3 in combination with a physiologically compatible vehicle suitable for use in orthopedic surgery for local application to a site of bone fracture or osteotomy, or for application to solid or semi-solid implants conventional in orthopedic surgery and to prostheses.