发明名称 |
CONTROLLED-RELEASE MULTIPLE UNITS PHARMACEUTICAL FORMULATION |
摘要 |
A pharmaceutical controlled release formulation is disclosed which does not substantially disintegrate but gradually releases a physiologically active substance in the gastrointestinal tract and which comprises a granulation product (granules) obtained by adding release controlling agent (e.g. an aqueous suspension of a water insoluble macromolecular substance, an aqueous emulsion thereof, a water containing organic-solvent solution thereof, or water) to a mixture of i) physiologically active substance and ii) carrier substance (e.g. crystalline cellulose) in an amount of at least 50% by weight based on the weight of the product, and granulating the resultant mixture. The active substance containing granules have a high mechanical strength, disperse widely in the gastrointestinal tract when administered, are water permeable but do not substantially disintegrate in the gastrointestinal tract. |
申请公布号 |
ZA8601565(B) |
申请公布日期 |
1986.10.29 |
申请号 |
ZA19860001565 |
申请日期 |
1986.03.03 |
申请人 |
YAMANOUCHI PHARMACEUTICAL CO.,LTD. |
发明人 |
MUNEO FUKUI;KOUJI TOMURO;SHIGERU MASUYAMA;ATSUSHI KAJIYAMA;TAMIO HIKOSAKA;MASSAYOSHI ARUGA;YOSHIAKI SOEISHI;SABURO HIGUCHI |
分类号 |
A61K9/16;A61K9/20;A61K9/22 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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