| 摘要 |
PURPOSE:An antiallergic agent, containing a specific flavone derivative as an active constituent, having improved liberation inhibitory activity of chemical mediators, e.g. histamine or SRS-A, by the oral administration with low toxicity. CONSTITUTION:An antiallergic agent containing a compound expressed by the formula (R is H or acetyl) or a pharmaceutically acceptable salt thereof as an active constituent. The compound expressed by the formula is capable of inhibiting the second stage of allergic reaction liberating chemical mediators, e.g. histamine or SRS-A, etc. to the outside of cell. Specific examples thereof include 7-hydroxy-8-nitroflavone, etc. The agent is administered preferably by the oral route in 0.1-500mg dose range. The agent is useful for prevention and treatment of various allergic diseases caused by the chemical mediators.
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