DIHYDROPYRIDINE, MANUFACTURE AND ANTIHYPERTENSIVE

摘要

A dihydropyridine of the formula: wherein R<1> and R<2> each is alkyl or alkoxyalkyl, wherein R<3> is alkyl, wherein R<4> is alpha-branched-chain alkyl, hydroxyalkyl, arylalkyl, aryloxyalkyl or acylaminoalkyl, wherein benzene ring A bears one or more substituents selected from halogeno, cyano, nitro, trifluoromethyl and alkyl or bears the substituent =N-O-N= attached to the 2- and 3-positions; wherein Ar is phenylene, naphthylene, tetrahydronaphthylene, indanylene or pyridylene which is unsubstituted or which bears one or more substituents, wherein p is 0 or 1; wherein q is 1, 2, 3 or 4; wherein X is -O-,-NH-, -NHCO- or -CONH; wherein X<1> is a direct link or is -O-, -S-, -NH- or -NHSO2-; and wherein Y is straight- or branched-chain alkylene which may optionally be interrupted by one or two groups selected from oxygen, sulphur, imino, substituted imino, phenylene, substituted phenylene, pyridylene, cycloalkylene, 1,4-piperazinediyl, 1,4-piperidinediyl and amido groups; or an acid-addition salt thereof, process for their manufacture and pharmaceutical composition containing them. The compound possess either beta-adrenergic blocking or calcium ion slow channel blocking properties, or both such properties, and may be used in the treatment of hypertension.