| 摘要 |
<p>Compounds of formula (I):
<CHEM>
and pharmaceutically acceptable salts thererof are disclosed wherein
m is 1 to 4;
n is 2 or 3;
r is 1 to 3;
A is, e.g., phenyl substituted with (R<1>)q wherein q is an integer of 1 to 5 and when there are more than one R<1>, R<1> can be the same or different from each other and is hydrogen; halo; loweralkoxy; lower alkenoyl; haloloweralkyl; cyano; hydroxyloweralkyl; or hydroxy; and
R, R<2> and R<3> independently are R<1>. Those compounds are prepared by (1) nucleophilic substitution involving an appropriately substituted 2,3-dihydrobenzofuranol (or 2,3-dihydrobenzopyranol) and a cinnamylhalide followed by reduction; or (2) by Wittig reaction involving a halomethyl derivative of 2,3-dihydrobenzofuran (or 2,3,-dihydrobenzopyran and an aryl or a heteroaryl aldehyde followed by reduction. These compounds were found to be potent antiinflammatory agents. </p> |
