| 摘要 |
PURPOSE:To obtain the titled compound useful as an intermediate for the synthesis of physiologically active substances, e.g. medicinal drugs such as digestive drug, etc., in high efficiency, by treating a gamma-halogenated crotononitrile with a particular microorganism is aqueous medium. CONSTITUTION:The objective optically active beta-hydroxy-gamma-halogenated butyronitrile can be produced by treating gamma-halogenated crotononitrile with a microbial strain such as Alcaligenes faecalis ATCC 15173, etc., in an aqueous medium, preferably at 4-8pH and 20-50 deg.C for 12hr-10 days.
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