发明名称 |
Novel nitropyrazinyl- and nitropyridinyl- substituted piperazin-3-one and hexahydro-1H-1,4-diazepin-5-one compounds useful as adjuncts to radiation therapy |
摘要 |
Novel nitropyrazinyl- and nitropyridinyl- substituted piperazin-3-one and hexahydro-1H-1,4-diazepin-5-one compounds are disclosed to have activity in increasing the sensitivity of hypoxic tumor cells to radiation. Also disclosed are methods of preparing such compounds and pharmaceutical compositions including such compounds.
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申请公布号 |
US4619927(A) |
申请公布日期 |
1986.10.28 |
申请号 |
US19850716884 |
申请日期 |
1985.03.27 |
申请人 |
MERCK & CO., INC. |
发明人 |
ENGELHARDT, EDWARD L.;SAARI, WALFRED S. |
分类号 |
A61K31/495;A61K31/55;A61P35/00;A61P43/00;C07D241/16;C07D241/20;C07D243/00;C07D401/04;C07D403/04;(IPC1-7):A61K31/55 |
主分类号 |
A61K31/495 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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