| 摘要 |
1. Claims for the Contracting States BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Phenethanolamine derivatives of the formula see diagramm : EP0198412,P14,F1 wherein n is the number 1 or 2, L**1 and L**2 are hydrogen or C!- #(alkyl or alkoxy)carbonyl, T is hydrogen or methyl, X**1 and X**2 are phenyl or phenyl which is monosubstituted in the m-position by Br, Cl, F, CF# or NO@, Y is a group -(CH@)!- DELTA O-G, -(CH@)!- DELTA CH=CH-C(O)-Z, -C(O)-Z or -CH(COOR")@, G is C!- $alkyl, C!- $alkoxy-C!- $alkyl or -(CH@)!- Ö$Q, Q is phenoxy, phenyl or p-fluoro- or p-phenoxy-phenyl, Z is a group OR or N(R,R'), and R and R' are hydrogen or C!- $alkyl or R and R' together with the N-atom to which they are attached from a 5- or 6-membered saturated ring which optionally contains an O-atom or an additional N-atom, and R" is C!- $alkyl, as well as physiologically compatible salts thereof. 1. Claims for the Contracting State AT A process for the manufacture of phenethanolamine derivatives of the formula see diagramm : EP0198412,P15,F4 wherein n is the number 1 or 2, L**1 and L**2 are hydrogen or C!- #(alkyl or alkoxy)carbonyl, T is hydrogen or methyl, X**1 and X**2 are phenyl or phenyl which is monosubstituted in the m-position by Br, Cl, F, CF# or NO@, Y is a group -(CH2 )!- DELTA O-G, -(CH@)!- DELTA CH=CH-C(O)-Z, -C(O)-Z or -CH(COOR")@, G is C!- $alkyl, C!- $alkoxy-C!- $alkyl or -(CH@)!- Ö$Q, Q is phenoxy, phenyl or p-fluoro- or p-phenoxy-phenyl, Z is a group OR or N(R,R'), and R and R' are hydrogen or C!- $alkyl or R and R' together with the N-atom to which they are attached form a 5- or 6-membered saturated ring which optionally contains an O-atom or an additional N-atom, and R" is C!- $alkyl, as well as of physiologically compatible salts thereof, characterized by a) etherifying a phenol corresponding to the phenol ether of formula I with an agent which introduces the group Y, or b) alkylating an amine of the formula see diagramm : EP0198412,P16,F1 wherein one of Q**1 and Q**2 is hydrogen and the other is hydrogen or a group Q of the formula see diagramm : EP0198412,P16,F2 or see diagramm : EP0198412,P16,F3 with an agent which introduces the group Q, and c) if desired functionally modifying a reactive substituent present in a group Y of the reaction product, if desired esterifying one or both hydroxy groups in the beta-position to the amine nitrogen atom and, if desired, converting a compound of formula I into a salt. |
