| 摘要 |
<p>PURPOSE:To obtain the titled substance useful as a base of skin-protection cosmetic, only by molecular distillation process, without leaving color and unagreeable odor, by reacting isophytol with tert-butyl hydroperoxide in the presence of a specific metal catalyst and opening the ring of the resultant product in the presence of an acidic catalyst. CONSTITUTION:1 mol of isophytol is made to react with preferably 1.0-1.3 mol of tert-butyl hydroperoxide in the presence of a metallic catalyst consisting of a derivative of vanadium or molybdenum at 50-150 deg.C, preferably 80-110 deg.C to obtain an epoxy compound. The epoxy compound is subjected to the ring- opening reaction in the presence of an acidic catalyst such as sulfuric acid. After the completion of the reaction, the reaction mixture is neutralized with an aqueous solution of an alkali such as sodium hydroxide and extracted with a solvent such as ether. The extract is washed with water, and the crude objective compound is subjected to molecular distillation to obtain the objective colorless and odorless transparent substance.</p> |
