| 摘要 |
<p>A process for the preparation 10???-methoxy-6-methyl-ergoline derivatives of formula (I> <IMAGE> wherein R is hydrogen or methyl, X is hydrogen, chlorine, bromine oriodine, R' is hydrogen or a 5-bromo-nicotinoyl group, and physiologically acceptable acid addition salts thereof, comprises photochemical methoxylations of a 2-halo-lysergol, optionally followed by modification of the groups at R, X and R<1>. The partly new compounds of formula (I) are valuable intermediates in the preparation of nicergoline, a potent peripheral vasodilator. Moreover, the compounds of formula (I) in which R is Hormethyl, R' is H and X is chlorine, bromine or iodine claimed per se, show D2-receptor blocking activity.</p> |
