FORBEDRET FREMGANGSMAATE FOR FREMSTILLING AV 3-BROMMETYL-3-CEFEM-SULFOKSYDDERIVATER.

摘要

Improved process for the preparation of brominated cephalosporanic derivatives, wherein a desacetoxy-3-cephem sulphoxide of general formula …… wherein R1 represents an acylamido group and R2 represents a group protecting the carboxy radical, is brominated in manner known per se and a compound of general formula …… in the reaction mixture or separated from such a reaction mixture is debrominated in the presence of a hydrogen donor and the 3-bromomethyl-3- cephem derivative of the general formula …… thus produced is recovered.