HEPATITIS B SURFACE ANTIGEN

摘要

There is disclosed a process for producing a proteinaceous mass containing particles of HBsAg in a morphological form not found in nature while inactivating any live virus contained therein. The process comprises subjecting a concentrated mass thereof free of protein diluent or a stabilizer to a heat inactivation by heating the same while in a concentration of at least 1 mg/ml at a temperature of 101 DEG to 105 DEG C. for 1 to 5 minutes and thereafter cooling the so heated particles.