| 摘要 |
PURPOSE:An antitumor agent which shows high antitumor activity and can be synthesized easily, containing a specific quadron analog compound as an active ingredient. CONSTITUTION:An antitumor agent containing 2- methylenetricyclo[3,3,3,0]undecan-3-one shown by the formula I, 7- methylenetricyclo[6,3,0,0<1.5>]undecan-6-one shown by the formula II or spiro[cyclopropane-1,11']-2'-methylenetricyclo[4,3,2,0<1>'<.5>']undeca n-3'-one shown by the formula III as an active ingredient. A dose of the compound is preferably 10-500mg to adult daily. The compound shown by the formula I is produced from a [4,3,2]propellanone shown by the formula IV as a starting raw material by a method corresponding to the reaction formula. The compound shown by the formula II is produced by the similar method from a 6-keto derivative prepared by acid catalyst rearrangement of a propellenone shown by the formula V.
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