Resolution of racemic mixtures of aliphatic acid esters.

摘要

Racemic mixtures of partially water-soluble esters defined by the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="21" wi="35" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R and R<Sub>1</Sub> represent hydrogen and C,-C<Sub>4</Sub> alkyl;
<UnorderedLists id="ula01" listStyle="none"><ListItem>R<Sub>2</Sub> represents C<Sub>1</Sub>-C<Sub>4</Sub> alkyl and</ListItem><ListItem>X represents halogen, aliphatic or aromatic groups and substituted derivatives thereof</ListItem><ListItem>wherein R, R<Sub>1</Sub> and X are different can be resolved by reducing the water solubility of a racemic mixture of said esters by means other than changing the chemical composition of the ester, contacting the racemic mixture of esters of reduced water solubility with a lipase enzyme from Candida cylindracea capable of stereospecifically resolving the racemic mixture by hydrolysis and stereospecifically resolving the racemic mixture.</ListItem></UnorderedLists>