| 摘要 |
<p>This invention relates to new chemical compounds possessing valuable pharmaceutical activity, particularly as lipoxygenase inhibitors possessing anti-inflammatory and anti-allergic properties. The present new compounds are of the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="16" wi="81" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>and salts thereof;
<UnorderedLists id="ula01" listStyle="none"><ListItem>wherein</ListItem><ListItem>R<Sub>2</Sub> is H, lower alkyl, formyl or C<Sub>2</Sub>-C<Sub>10</Sub> alkanoyl;</ListItem><ListItem>R and R, are each independently hydrogen, lower cycloalkyl, fused cycloalkyl or lower alkyl-substituted fused cycloalkyl, lower alkyl, phenyl, naphthyl or a nitrogen, oxygen, or sulfur heterocyclic ring or heterocyclic-lower alkyl;</ListItem><ListItem>Z, Z, and Z<Sub>7</Sub> are each a chemical bond, or an alkylene chain or a mono- or di-substituted alkylene chain containing up to 6 carbon atoms in the principal chain and up to a total of about 10 carbon atoms, a lower cycloalkyl, a nitrogen oxygen, or sulfur heterocyclic ring or heterocyclic-lower alkyl, or a mono- or di-subsituted lower cycloalkyl or heterocyclic lower alkyl, and the substituents are hydrogen, lower alkyl, aryl, lower aralkyl, lower alkoxy, hydroxy, lower aralkoxy, aryloxy, carboxy, lower carbalkoxy, carbaryloxy, lower carbaralkoxy, amino, lower alkyl amino, amino loweralkyl, di-loweralkylamino or cyano;</ListItem><ListItem>X and Y are each independently 0, S, CR<Sub>3</Sub> R<Sub>4</Sub> or a chemical bond;</ListItem><ListItem>R<Sub>3</Sub> and R<Sub>4</Sub> are each independently H or lower alkyl; each R<Sub>5</Sub> is hydrogen, aryl, lower alkarayl, formyl, nitro, cyano, amino, lower aminoalkyl, lower alkylamino, lower aralkylamino, halo, trihalo alkyl, carbamoyl or aroyl;</ListItem><ListItem>n is an integer from 0-2; and</ListItem><ListItem>n, is an integer from 1-2.</ListItem></UnorderedLists></p> |
