2'-CHLOROPENTOSTATIN COMPOUND AND MANUFACTURE

摘要

The compound 2 min -chloropentostatin, which has the formula is a potent inhibitor of the enzyme adenosine deaminase and possesses utility as an agent for potentiating the activity of antiviral agents for the treatment of DNA viruses which agents contain an adenine moiety, such as 9-(beta-D-arabinofuranosyl) adenine. A pure strain of actinomycete, designated ATCC 38365 which is capable of producing 2 min -chloropentostatin, a method of producing 2 min -chloropentostatin by aerobic fermentation, and pharmaceutical compositions including 2 min chloropentostatin are also disclosed.