发明名称 |
Method for selective methylation of erythromycin a derivatives. |
摘要 |
<p>A method for the selective methylation of the hydroxy group at the 6-position of erythromycin A derivatives which comprises reacting a compound represented by the formula R-X (wherein R is a 2-alkenyl group, a benzyl group or a substituted benzyl group, and X is a halogen atom), reacting the resulting quaternary salt compound with a methylating agent, and then eliminating R groups of the resulting compound to give 6-0-methylerythromycin A 9-oxime, is disclosed.</p> |
申请公布号 |
EP0195960(A1) |
申请公布日期 |
1986.10.01 |
申请号 |
EP19860102854 |
申请日期 |
1986.03.05 |
申请人 |
TAISHO PHARMACEUTICAL CO. LTD |
发明人 |
MORIMOTO, SHIGEO;ADACHI, TAKASHI;ASAKA, TOSHIFUMI;KASHIMURA, MASATO;WATANABE, YOSHIAKI;SOTA, KAORU |
分类号 |
C07H17/08;(IPC1-7):C07H17/08 |
主分类号 |
C07H17/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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