| 摘要 |
The vaccine comprises an antigen derived from at least partly undenatured or partially structured fusion-protein expressed by a bacterium which has been transformed with a plasmid comprising a gene fragment from the virus against which the vaccine is intended to act. Anti-viral serum may be generated from the vaccine by immunising rabbits or mice with the fusion-protein. The VP7c neutralisation antigen of bovine rotavirus is produced as a fusion protein with beta -galactosidase under the control of the temperature inducible lambda PR promoter. The plasmid may be established in E. coli which can be used as the vaccinating agent. |
