PROCESS FOR PREPARING N-SUBSTITUTED DERIVATIVES OF PHOSPHONIC ACID

摘要

Phosphonic acid diesters having the formula: in which R represents a hydrogenolysable group, preferably an aralkyl group, and R<1> represents a hydrolysable group, are obtained by a process wherein phosphonic acid esters of the formula (R<1>O)2P(O)H are reacted with formaldehyde and compounds of the formula R-NH-CH2-COOH, R and R<1> having the meanings given above. Compounds of the formula may be obtained by hydrogenolysis of the above compounds.