| 摘要 |
<p>The invention relates to a process for the preparation of the compound of the formula I, <IMAGE> I which comprises (a1) splitting off the ethylene ketal protecting group from the azetidinone derivative of the formula IVa, <IMAGE> IVa reducing the compound of the formula III thus obtained, <IMAGE> III treating the resulting compound of the formula II <IMAGE> II with concentrated aqueous hydrogen chloride solution; or (a2) reducing the compound of the formula III, treating the compound of the formula II thus obtained with concentrated aqueous hydrogen chloride solution; or (a3) treating the compound of the formula II with concentrated aqueous hydrogen chloride solution; and isolating the compound of the formula I thus obtained from the reaction mixture. The compound of the formula I is useful as an intermediate in the production of thienamycin, a highly potent antibiotic.</p> |
| 申请人 |
RICHTER GEDEON VEGYESZETI GYAR RT,HU |
发明人 |
LEMPERT,KAROLY,HU;DOLESCHALL,GABOR,HU;PETTER,JOZSEF,HU;HORNYAK,GYULA,HU;NYITRAI,JOZSEF,HU;SIMIG,GYULA,HU;ZAUER,KAROLY,HU |
