| 摘要 |
<p>Compounds Ia <CHEM> with R = H protecting group R<1> = H, alkyl R<2> = H, protecting group or salts thereof are prepared by (1) producing compound Ib <CHEM> with Z = -NHR<3>, -NR<3>R<3>,-NR<1>R<3>,-R<4>, OH R<3> protecting group R<4> = carboxyl activating group or -COZ being -CN by (A) heating II <CHEM> (B) reacting IV <CHEM> with III <CHEM> y being a leaving group (C) cyclising Va, Vb or Vc <CHEM> (L<1> = Cl,Br) (D) cyclising VIa, VIb, VIc, VId <CHEM> <CHEM> X = O, S R<5> = Cl, Br R<6> = Cu(II), P(II) or Hg(II) (E) cyclising VIIIa or VIIIb <CHEM> L being a leaving group and (2) removing protecting groups, reacting COZ groups with ammonia of methylamine or converting COZ or CN groups into CONHR<1>. (3) converting a compound Ia into another compound Ia. These penem compounds have antibacterial properties.</p> |
