发明名称 |
Stabilized injection compositions and their preparations. |
摘要 |
<p>The invention relates to a process for the preparation of colour and pH stabilized aqueous parenteral pharmaceutical compositions comprising an antibacterial aminoglycoside comprising a pyranose ring being unsaturated between positions 4 min and 5 min and substituted with an aminoalkyl group at position 5 min , preferably sisomicine, netylmicine or 5-episisomicine or the parenterally acceptable salts thereof. According to the process of the invention the active ingredient is dissolved in water, the pH of the solution is adjusted to 7,3 - 7,4, an antioxidant is added to the solution, nitrogen gas is bubbled through the solution after sterile filtration and the solution thus obtained is filled into ampoules.</p> |
申请公布号 |
EP0195114(A2) |
申请公布日期 |
1986.09.24 |
申请号 |
EP19850109621 |
申请日期 |
1985.07.31 |
申请人 |
CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. |
发明人 |
KALOY, KATALIN, DR.;SOMFAI, EVA, DR.;JARAY, MIKLOS, DR.;KOVACS, ENIKO |
分类号 |
A61K31/70;A61K9/00;A61K9/08;A61K31/00;A61K31/7028;A61K31/7034;A61K31/7036;A61K47/02;A61K47/18;A61P31/04;C07H15/222;(IPC1-7):A61K9/00;A61K47/00 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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