| 摘要 |
2-Arylimidazol[4,5-c]pyridines having the formulae <CHEM> and <CHEM> or a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, allyloxy, propargyloxy, benzyloxy, (C1-C4 alkyl)thio, (C1-C4)alkyilsulfinyl, (C1-C4 alkyl)sulfonyl, hydroxy, halo, cyano, nitro, amino, mono- or di-(C1-C4 alkyl)amino, trifluoromethyl, or Z-Q-substituted C1-C4 alkoxy, wherein Q is oxygen, sulfur, sulfinyl, sulfonyl, or a bond, and Z is C1-C4 alkyl, phenyl or phenyl substituted with halo, C1-C4 alkyl, C1-C4 alkoxy, hydroxy, nitro, amino, (C1-C4 alkyl)thio, (C1-C4 alkyl)sulfinyl, or (C1-C4 alkyl)sulfonyl; Y is -O- or -NH-; G is C = O or -S(O)r-, where r is 0, 1, or 2; and R2 is C1-C4 alkyl, phenyl, trifluoromethyl, or -NR3R4, where each of R3 and R4 is independently hydrogen or C1-C4 alkyl; with the limitations that when R2 is trifluoromethyl or -NR3R4, and G is -S(O)r-, r may not be 0 or 1, and with the further limitation that when Y is -O- and G is -S(O)r-, r may not be 0 or 1. The compounds are useful for treating a mammal, including a human, suffering from or susceptible to the conditions of asthma, thrombosis, hypertension, or heart failure. |
