| 摘要 |
NEW MATERIAL:The polyprenyl compound of formula I [all of A, B, Y and Z are H, or A and B or Y and Z together form a single bond; n is 0-2; X is group of formula II (both K and L are H or K and L together form a single bond), CH2 or (CH2)2; m is 0 or 1; R is OH, group of formula III (R<1> and R<2> are H or lower alkyl; p is 1 or 2), NH-(CH2)q-OH (q is 1 or 2), etc.] and its salt. EXAMPLE:4-(2',6',10'-Trimethylundecyl)phenylacetic acid. USE:It has excellent hypocholesteric action, and is useful as an hypocholesteric agent and remedy for arteriosclerosis. PREPARATION:A compound of formula I wherein m is 0 and R is OH can be produced, e.g. by reacting the compound of formula IV with the compound of formula V (n is 0-2) in the presence of a catalyst, is a solvent at room temperature -100 deg.C, and hydrolyzing the reaction product.
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