PROCESS FOR PREPARING 1,1-ALKANEDIOL DICARBOXYLATE LINKED ANTIBACTERIAL AGENTS

摘要

Alkanediol dicarboxylate diesters (I) [A=alkylene, alkylidene, cycloalkylene, phenylene, naphtalene, alkylene substd. by 5or 6- membered heterocyclic gps.; R3=H, alkyl; n=0-1; R≠R1; R= penicillin esters, penicillanate, penicillanate dioxodes etc.; if n=0, R1=H, alkyl, Bz, (HCR3)Cl,CH(R3)I or Bu4NH4; if n=1, R1=R! and their acid- addn. salts were prepd. Thus, II was obtd. from Na penicillanate dioxide, ampicillin, and K benzyl trans-1,4-cyclohexanedicarboxylate, ClCh2I, and BrCH2Cl in 10 steps.