| 摘要 |
<p>A sustained release drug delivery device, for use in the rumen of a ruminant animal, of the type having a hydrolyzable biodegradable polymeric core in which a medicament beneficial when administered to the digestive tract of the ruminant animal is dissolved or suspended, which core is contained in a tube which is compatible with the rumen and which has at least one open end, which comprises a relatively thick layer of elastic sealent filling the length of the annulus between the core and the tube and forming an adhesive bond to both the core and the tube, said sealent being substantially impermeable to water, compatible with both the tube and the core, and compatible with and unaffected by the rumen is provided by the present invention.</p> |
