| 摘要 |
Penams I [R1=H, 3-phthalidyl, 4-chrotonolactonyl, γ-butyrolacton-4- yl, -C.R4-O-COR5, -C.R3.R4-O-COR6; R2=CN, CO-Z; R3, R4=H, CH3; R5=C1-5 alkyl or alkoxy; R6=Fig. II; X=H,OH; Y=azido, amino; Z=C1-4 alkoxy, C2-4 Ω-hydroxyalkoxy, C3-6 carboalkoxymethoxy, C1-4 dialkylamino! were prepd. Thus, benzyl-2-β- hydroxymethyl-2-α-methyl-(5R)-penam-3-α-carboxylate in acetone-water mixt. was treated with KMnO4 and then water-ethyl acetate mixt. was added to give benzyl-2-β-carboxy-2-α- methyl(5R)-penam-3-α-carboxylate.
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