| 摘要 |
PURPOSE:To provide the titled bathing agent composed of sulfamic acid, sodium carbonate and fumaric acid, effective to prevent the sticking in tableting operation, and capable of elongating the foaming period. CONSTITUTION:The objective foamable bathing agent can be produced by adding sodium carbonate and fumaric acid (as a lubricant) to sulfamic acid. Although a highly pure sulfamic acid may be used for the purpose, the sue of sulfamic acid having somewhat low purity (95% purity) is effective to elongate the reaction period because the acid contains impurities inert to Na2CO3. CO2 gas is generated by the neutralizing reaction of sulfamic acid and sodium carbonate and the effect of the bathing agent can be promoted by the warming effect of the gas and the stimulation caused by the formation of gas bubbles. Fumaric acid eliminates the problems in the continuous tableting process, e.g. capping, sticking, etc., and acts also as an organic acid in place of the sulfamic acid. |
