| 摘要 |
PURPOSE:To produce a freeze-dried mixed vitamin preparation containing a fat-soluble vitamins stably in the same container, by compounding dextran or sucrose as a vehicle. CONSTITUTION:A stable freeze-dried mixed vitamin preparation is obtained by compounding dextran or sucrose as a vehicle. The preparation is obtained e.g. by solubilizing fat-soluble vitamins (e.g. vitamin A1, D3, E, etc.) preferably in a nonionic surfactant, separately dissolving water-soluble vitamins (e.g. vitamin B1, B2 C, etc.) in water adjusting the pH of the solution to 5-6, mixing the obtained liquids with each other, adding about 1/2-2 times volume of dextran or sucrose based on the main drug, adjusting the concentration of the main drug to 1-10% and freeze-drying the mixture. The process has especially excellent stabilizing effect to vitamins A, B1 and B2.
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