摘要 |
<p>A process for the manufacture of a polypeptide (I) having the formula:<Image id="ia01" he="44" wi="130" file="IMGA0001.TIF" imgContent="dna" imgFormat="TIFF" inline="no" /><!-- EPO <DP n="2"> -->which comprises steps of:
<UnorderedLists id="ula01" listStyle="none"><ListItem>(a) coupling, successively and in the order of the sequence of the polypeptide (I), the four protected fragments A, B, C and D or five protected fragments A, B, C, E and F,</ListItem><ListItem>said fragment A by the formula, Leu-Gln-Asp-Ile-Met-Ser-Arg-NH<Sub>2</Sub></ListItem><ListItem>said fragment B by the formula, Gln-Leu-Ser-Ala-Arg-Lys-Leu</ListItem><ListItem>said fragment C by the formula, Arg-Lys-Val-Leu-Glysaid fragment D by the formula, Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr</ListItem><ListItem>said fragment E by the formula, Ile-Phe-Thr-Asn-Ser-Tyr and said fragment F by the formula, Tyr-Ala-Asp-Ala being represented, respectively, and</ListItem><ListItem>(b) eliminating, at the end of sequence, all the protecting groups to provide the polypeptide (I) which is active on the stimulation of the release of the growth hormone and thus is very useful as medicine for treatment of growth hormone deficiency disease and the like.</ListItem></UnorderedLists></p> |
申请人 |
SUMITOMO PHARMACEUTICALS COMPANY, LIMITED |
发明人 |
ONO, KEIICHI;KAI, YOSHIYUKI;TAKEBAYASHI, YOSHIAKI;SANO, AKIHIKO;SUWA KAZUSHI |