Analogous interferon polypeptides, process for their preparation and pharmaceutical compositions containing them.

摘要

Analogues of human interferon alpha2 in which an amino acid is present in at least one position selected from interferon alpha2 positions 12-16, 21, 27-32, 37, 43a, 44, 59, 61, 64, 67, 98-115, 137-138 and 148 which differs from the amino acid in the corresponding position of interferon alpha2, possess good antiviral activity and may additionally be used as biochemical tools. The interferon analogues are prepared by culturing a microorganism, the microorganism having been transformed with a replicable plasmidic expression vehicle comprising genetic material coding for the said interferon analogue.