| 摘要 |
<p>Products of Aspergillus alliaceus fermentation with the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="63" wi="57" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry><Chemistry id="chema02" num="0002"><Image id="ia02" he="56" wi="62" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry><!-- EPO <DP n="2"> -->or
<Chemistry id="chema03" num="0003"><Image id="ia03" he="52" wi="77" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>and salts and quaternary ammonium salts thereof, wherein X is N or C and R<Sub>1</Sub>, R<Sub>2</Sub> and R<Sub>3</Sub> are H, F, and CH<Sub>3</Sub>, and R<Sub>4</Sub> is selected from phenyl, cyclohexyl, cyclopentyl, (CH<Sub>3</Sub>)<Sub>2</Sub>CH-CH<Sub>2</Sub>- , (CF<Sub>3</Sub>) (CH<Sub>3</Sub>) CH-CH<Sub>2</Sub>-. CH<Sub>2</Sub>=C(CH<Sub>3</Sub>)CH<Sub>2</Sub>-, CH<Sub>2</Sub>=CHCH<Sub>2</Sub>-, CH<Sub>3</Sub>-CH<Sub>2</Sub>-CH<Sub>2</Sub>-, CH<Sub>3</Sub>-CH<Sub>2</Sub>-(CH<Sub>3</Sub>)CH-, CH<Sub>3</Sub>-(CH2)<Sub>3</Sub>-, CH<Sub>3</Sub>-S-(CH<Sub>2</Sub>)<Sub>2</Sub>-, and CH<Sub>3</Sub>-CH<Sub>2</Sub>-S-CH<Sub>2</Sub>- such that R<Sub>1</Sub> R<Sub>2</Sub> and R<Sub>3</Sub> are all H only when R<Sub>4</Sub> is other than (CH<Sub>3</Sub>)<Sub>2</Sub>-CH-CH<Sub>2</Sub>-, having a cholecystokinin (CCK) antagonist activity, their preparation and use.</p> |
