| 摘要 |
The novel 2-aminopurine derivatives disclosed herein which have a hydrogen atom in the 6-position and an acyclic chain <IMAGE> in the 9-position [wherein X=O or S, Y=H or CH2OR and R=H or <IMAGE> wherein R DEG =H, C1-16 alkyl (preferably C1-6 alkyl), optionally substituted aralkyl or optionally substituted aryl, provided at least one R is <IMAGE> are converted in vivo by the action of xanthine oxidase/dehydrogenase or aldehyde oxidase and esterase enzymes into the corresponding 6-hydroxy compounds wherein R=H, which are potent antiviral compounds.
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