Process for the preparation of gamma-globulin for intravenous injection

摘要

gamma -Globulin is treated with pepsin or uropepsin in a neutral pH range from 6.0 to 7.5. During this there is selective breakdown of the aggregates in gamma -globulin, whereas there is essential avoidance of any breakdown of monomeric gamma -globulin. The resulting gamma -globulin can be administered intravenously without adverse effects and displays no loss of opsonin activity. The therapeutic composition for intravenous injection with reduced anticomplementary activity is stabilised by adding uropepsin to human gamma -globulin. The uropepsin acts simultaneously as proteolytic enzyme and stabiliser in this case. Uropepsinogen can also be used as stabiliser.