| 摘要 |
PURPOSE:To separate the titled compound useful as pharmaceuticals, etc., in high yield and purity, by the chromatographic development of a mixed solution containing phenylalanine and cinnamic acid using a synthetic adsorbent under a specific condition. CONSTITUTION:A mixed solution containing phenylalanine and cinnamic acid is subjected to the chromatographic development using a synthetic adsorbent adjusting the concentration of the organic acid salt in the solution to >=0.2N, preferably >=0.5N to effect the separation of phenylalanine and cinnamic acid. The synthetic adsorbent is e.g. 'Diaion' HP10, 20, etc., (product of Mitsubishi Chem. Ind. Co. Ltd.), etc., having a surface area of >=100m<2>/g and a pore volume of >=0.1ml/g. The concentration of the phenylalanine and cinnamic acid in the mixed solution is about 0.05-20W/V% each.
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