摘要 |
NEW MATERIAL:A glycoprotein coriolan having the following characteristics. Elemental analysis, C 50.0-52.0%, H 7.2-8.2%, N 2.0-6.0%, the rest part is O; color reactions, shown in the table I; pH, 4.4 as a solution obtained by dissolving 0.1g of the compound in 100cc of water; molecular weight, >=2,000,000 (gel-filtration, etc.); solubility, soluble easily in water and insoluble in acetone, etc.; composition of the constituent sugars, shown in the Table II; composition of the constituent proteins, shown in the Table III; ratio of protein to sugar, 1:2-4; color, white (freeze-dried product); decomposition point, 223 deg.C (by scanning differential thermal balance). USE:Antitumor agent. PREPARATION:The cultured product, fruit body, or mycelia of Coriolus pubescens is extracted with an aqueous solvent at <=50 deg.C, preferably at 0-30 deg.C, and subjected to gel-filtration to obtain the objective glycoprotein coriolan having a molecular weight of >=2,000,000. It can be administered by intravenous injection, oral administration or rectal infusion, at a dose of preferably <=500mg daily for injection and <=5g daily for oral administration.
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