NOVEL PEPTIDE AND PEPTIDE DERIVATIVE, MANUFACTURE AND MEDICINAL COMPOSITION

摘要

The peptide such as a compound of formula I optionally in isosteric form, comprises a methylene group in the backbone chain which is disubstituted at R1 and R2, one or both substituents being fluorine and/or chlorine. The peptide preferably comprises a statine or statone residue. Such peptides are useful as enzyme inhibitors eg as renin inhibitors. They are useful in the prophylaxis or treatment of hypertension and congestive heart failure.