摘要 |
<p>A process for preparing a 4-substitued pyridine product from a starting pyridine substituted in the 4-position by a leaving group susceptible to nucleophilic displacement when the starting pyridine is in quaternized form, comprises,
<UnorderedLists id="ula01" listStyle="none"><ListItem>quaternizing the starting pyridine under effective acidic conditions with acrylamide, N-monoalkylacrylamide or N-dialkylacrylamide,</ListItem><ListItem>subjecting the resultant, corresponding quaternized starting pyridine, to a nucleophilic displacement reaction</ListItem><ListItem>with a reagent which reacts with it to produce the corresponding quaternary salt of the 4-substituted pyridine product, and</ListItem><ListItem>dequaternizing the latter under effective basic conditions to liberate the 4-substituted pyridine product.</ListItem></UnorderedLists></p> |