| 摘要 |
Compounds of structure (I) …<CHEM>… in which, R<1> is -CH2CR<2>R<3>NR<4>R<5> or YCOR<6>; R<2> is hydrogen or C1-4alkyl; R<3> is hydrogen or -COR<6>; R<4> is hydrogen or C1-4alkyl; R<5> is hydrogen, C1-4alkyl or C1-4alkanoyl; R<6> is hydroxy, C1-4alkoxy, or -NR<4>R<5>; Y is a bond or C1-4alkylene; R<7> and R<8> are the same or different and are each hydrogen, halogen, C1-4alkyl, nitro or amino; X is oxygen, sulphur, or CH2; R<9> is hydroxy or a bioprecursor theri20; R<1><0> is hydrogen or C1-4alkyl; and Ar is 4-hydroxyphenyl, 5-hydroxy-2-pyridyl, 6-oxo-3(1H)-pyridyl or a 6-oxo-3(1H)-pyridazinyl group and pharmaceutically acceptable salts thereof, processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them and their use in therapy as antihyperlipidaemic agents. |
