发明名称 |
1-hydroxy-1,1-diphosphonic acids and cytostatic use thereof |
摘要 |
1-hydroxy-1,1-diphosphonic acid compounds corresponding to the following general formula <IMAGE> (I) in which R and R1 represent hydrogen or methyl, X represents hydrogen, halogen, amino, which may be acyl substituted, lower alkyl, which may be substituted by amino or acyl substituted amino, or lower alkoxy, Y represents O, S or NH Z represents lower alkylene, which may be substituted by amino or acyl substituted amino, and m and n have the value 0 or 1 with the proviso that, where n is 1, m is also 1; and to pharmacologically compatible salts thereof. The invention also relates to a process for producing these compounds and to their use in pharmacological preparations having cytostatic activity.
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申请公布号 |
US4608368(A) |
申请公布日期 |
1986.08.26 |
申请号 |
US19850753479 |
申请日期 |
1985.07.10 |
申请人 |
HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN |
发明人 |
BLUM, HELMUT;GREB, WOLFGANG;MOELLER, HINRICH;SCHMAEHL, DIETRICH;SCHNEGELBERGER, HARALD;SINN, HANNSJOERG;WINGEN, FRANZ |
分类号 |
A61K31/66;A61P35/00;C07F9/38;C07F9/40;(IPC1-7):C07F9/38;A61K31/085;A61K31/10;A61K31/135 |
主分类号 |
A61K31/66 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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