| 摘要 |
PURPOSE:To obtain a tablet resistant to coagulation even under a low pH condition, and dissolving rapidly in gastric juice to solubilize the active component, by compounding a sucrose fatty acid ester containing more than a specific amount of a monoester. CONSTITUTION:A sucrose fatty acid ester containing >=90% monoester and preferably containing a 8-22C fatty acid such as octanoic acid, lauric acid, stearic acid, oleic acid, etc., as the constituent fatty acid, is used as a component of a tablet at a ratio of >=50wt%. The dissolution of the active component in the gastric juice can be accelerated and the quick drug action can be attained by this method. Sucrose fatty acid ester is a nonionic surfactant having high safety, and is used widely in the fields of food, medicine, and cosmetic. Conven tional sucrose fatty acid ester forms a coagulum at a low pH and loses its dispersing power and solubilizing power. In contrast to the above, its monoester does not cause the coagulation even in a low pH region and has excellent solubilizing power to a water-insoluble component.
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