| 摘要 |
PURPOSE:To obtain the titled compound useful as a raw material for perfumery and amino acid, in high yield and selectivity, by reacting an aniline compound with an ethylene glycol compound in the presence of a catalyst controlling the maximum temperature of the reaction mixture at a specific level. CONSTITUTION:An indole compound is produced from an inexpensive raw material in short step, by reacting an aniline compound with an ethylene glycol compound in the presence of a solid acid catalyst such as SiO2-ZnO-AgO, cadmium sulfide, cadmium sulfate, etc. or a metallic catalyst such as Ag, etc., supported on a carrier having large specific surface area, in vapor phase. In the above process, the maximum temperature of the reaction raw material mixture containing the aniline compound and the ethylene glycol compound in the preheating stage before introducing into the reaction zone is suppressed to <=400 deg.C, usually to 250-400 deg.C, preferably to 300-390 deg.C to prevent the lowering of the selectivity of the objective compound.
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