发明名称 STABILA SULFO-ADENOSYL-L-METIONIN (SAME)-SALTER SOM AER SPECIELLT LAEMPLIGA FOER ORAL FARMACEUTISK ANVAENDNING.
摘要 This invention relates to new stable sulpho-adenosyl-L-methionine (SAMe) salts and the relative production process. Said salts have the following general formula: SAMe.nR(O)m(SO3H)p (I) where m can be zero or 1; n is 1.5 when p is 2, and is 3 when p is 1; R is chosen from the group consisting of alkyl, phenylalkyl and carboxyalkyl, in which the linear or branched alkyl chain contains from 8 to 18 carbon atoms. In particular, the salts according to the present invention are SAMe salts of sulphonic acids, or of sulphuric acid esters, or of dioctylsulphosuccinic acid, which fall within formula (I). The process for producing said salts consists of: a) enriching the starting yeast with SAMe; b) lysing the cells and recovering an aqueous solution rich in SAMe (cell lysate); c) purifying the lysate by ultrafiltration; d) precipitating the SAMe by treatment with one of the aforesaid acids or esters; e) separating the precipitated product, washing it and drying it under vacuum.
申请公布号 FI851953(L) 申请公布日期 1985.11.17
申请号 FI19850001953 申请日期 1985.05.16
申请人 BIORESEARCH SPA. 发明人 GENNARI, FEDERICO
分类号 C07H19/167;A61K9/02;A61K9/20;A61K9/48;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7076;A61K47/20;C07H19/16;C12N1/06;C12P13/12;C12P19/40;C12R1/645 主分类号 C07H19/167
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