7-n-aminomethylenemitomycin derivatives, process for production thereof and anti-tumor composition.

摘要

Mitomycin derivatives represented by the formula (I):
<Chemistry id="chema01" num="0001"><Image id="ia01" he="26" wi="81" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>
wherein R<Sub>1</Sub> and R<Sub>2</Sub> may be the same or different, and represent a hydrogen atom or a lower alkyl group: R<Sub>3</Sub> and R<Sub>4</Sub> mean that when R<Sub>3</Sub> is a hydrogen atom, R<Sub>4</Sub> represents -CH<Sub>2</Sub>0CONH<Sub>2</Sub> or
<Chemistry id="chema02" num="0002"><Image id="ia02" he="15" wi="44" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>
(wherein R<Sub>1</Sub> and R<Sub>2</Sub> have the same significances as defined above), or R<Sub>3</Sub> and R<Sub>4</Sub> are combined to form =CH<Sub>2</Sub>; Y and Z may be the same or different, and represent a hydrogen atom for a methyl group; <Image id="ia03" he="4" wi="11" file="IMGA0003.TIF" imgContent="character" imgFormat="TIFF" inline="yes" /> represents a- or β-bond, provided that

Y represents a hydrogen atom when R<Sub>4</Sub> takes β-conflguration, have an excellent antitumor activity.