| 摘要 |
<p>The invention relates to compounds of formula (I), <CHEM> wherein R<1> represents a C3-7 cycloalkyl-(C1-4) alkyl group or a C3-10 alkynyl group; and one of the groups represented by R<2>, R<3> and R<4> is a hydrogen atom or a C1-6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl or phenyl-(C1-3) alkyl group and each of the other two groups which may be the same or different, represents a hydrogen atom or a C1-6 alkyl group; and physiologically acceptable salts and solvates, e.g. hydrates, thereof. The compounds are potent selective antagonists at 5-hydroxytryptamine receptors and are useful in the treatment of psychotic disorders such as schizophrenia or mania and in the treatment of anxiety, pain, gastric stasis, symptoms of gastrointestinal dysfunction, migraine and nausea.</p> |
