| 摘要 |
Compounds of the formula <IMAGE> in which R1 and R2 independently of one another denote hydrogen, lower alkyl or aryl or, taken together, denote lower alkylene, one of the radicals R3 and R4 represents the group =N-R (Ia), in which R represents the group -O-Ra (Ib) and Ra represents hydrogen, lower alkyl, carboxy-lower alkyl or lower alkoxycarbonyl-lower alkyl or R represents the group -N(Rb)-Rc (Ic) and Rb and Rc independently of one another represent hydrogen or lower alkyl or one of the radicals Rb and Rc represent hydrogen and the other radical represents the group -C(=X)-Rd, in which X denotes oxo and Rd denotes lower alkoxy, di-lower alkylamino-lower alkyl, tri-lower alkylammonio-lower alkyl, lower alkyleneamino-lower alkyl, oxa-lower alkyleneammonio-lower alkyl, thia-lower alkyleneamino-lower alkyl, aza-lower alkyleneamino-lower alkyl which is optionally aza-substituted by lower alkyl or denotes pyridinio-lower alkyl or X denotes oxo or thioxo and Rd denotes amino, or both radicals Rb and Rc, taken together, denote lower alkylene, oxa-lower alkylene, thia-lower alkylene or aza-lower alkylene which is optionally aza-substituted by lower alkyl, and the other of the two radicals R3 and R4 has the same meanings or denotes oxo, and the ring A has no other substituents or is additionally substituted by lower alkyl, lower alkoxy and/or halogen, and salts of compounds of this type have salt-forming properties are active in retrovirus-induced Rauscher leukaemia of the mouse and can therefore be used therapeutically, for example in the control of immune diseases or autoimmune diseases likewise caused by retroviruses. |
