PROCESS FOR THE PREPARATION OF 2-/E/PHENYL- METHYLENECYCLOHEPTAN-1-ONE-/E/-OXIME

摘要

The invention relates to a process for the preparation of 2-/E/-phenylmethylenecycloheptan-1-one-/E/-oxime of the formula /I/ < IMG > /I/ free of other isomers. According to the invention the compound of the formula /I/ is prepared by reacting 2-/E/-phenylmethylene-cycloheptzn-1-one of the formula /II/ < IMG > with hydroxylamine obtained "in situ" from a hydroxylamine salt in the presence of a base. The reaction is carried out in water and/or in a lower, with water unrestrictedly miscible aliphatic alcohol, and subsequently the alcohol content of the reaction medium is adjusted to 40-60 %. The compound of the formula /I/ is isolated from the reaction mixture by known methods. The 2-/E/-phenylmethylenecycloheptan-1-one-/E/-oxime of the formula /I/ serves as intermediate for the synthesis of compounds possessing valuable pharmaceutical properties.