发明名称 |
Ethoxy:carbonyl phenyl-propyl l-alanyl l-proline |
摘要 |
1-(N-(1-ethoxycarbonyl 3-phenyl propyl) L-alanyl)L-proline and its acceptable salts are made by reductive amination of ethyl 2-oxo 4-phenyl butanoate with L-alanyl L-proline under phase transference conditions. Reaction is in inert organic solvent e.g. CH2Cl2 or benzene, with sodium cyano-borohydride in presence of a tetra-alkyl ammonium halide with 1-20C alkyl chains, as phase transfer catalyst.
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申请公布号 |
ES8605230(A1) |
申请公布日期 |
1986.08.16 |
申请号 |
ES20010005494 |
申请日期 |
1985.11.29 |
申请人 |
SERVICIOS Y SUMINISTROS FARMACEUTICOS, S.A. |
发明人 |
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分类号 |
A61K31/40;C07D207/08;(IPC1-7):C07D207/08 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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