Process for making 1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene

摘要

7 - Acetyl - 1,1,3,4,4,6 - hexamethyl - 1,2,3,4 -tetrahydronaphthalene is obtained by reacting the basic hydrocarbon (see Division C5) with acetyl chloride. In an example the acetylation is effected in the presence of aluminium chloride in ethylene dichloride at 20-22 DEG C. The product is a musk odorant.ALSO:1,1,3,4,4,6 - hexamethyl - 1,2,3,4 - tetrahydronaphthalene is obtained by reacting a dimethyl-p-tolylcarbinyl halide with tert.-butylethylene in the presence of a Friedel-Crafts catalyst at a low temperature, e.g. - 10 DEG C. to ambient temperature. a ,p-Dimethylstyrene is reacted with hydrogen chloride, the product, with or without isolation or purification, mixed with 0.8-1.2 mols of olefin per mol of halide and the mixture added slowly to 2-10% of aluminium chloride, based on the combined weight of reactants, suspended in ethylene dichloride, carbon tetrachloride, nitrobenzene or nitromethane. The 7-acetyl derivative is a musk odorant (see Division C2).