5 ALKYL 1,6-NAPHTHYRIDIN-2 (1H) ONES,THEIR PREPARATION AND THEIR CARDIOTONIC COMPOSITIONS

摘要

Naphthyridines of formula (I) …… , where R is -alkyl, R min is hydrogen or methyl, R sec is hydrogen or alkyl, and Q is hydrogen, hydroxy, amino, cyano, carbamyl, carboxy or aminocarbamyl, are useful as cardiotonic agents (I, Q is hydrogen, hydroxy, amino, cyano or carbamyl) and/or intermediates therefor (I, Q is carboxy, aminocarbamyl, hydrogen, amino, cyano or carbamyl). Also shown are pyridinones of formula II …… where R and R min are as above and Q min is hydrogen or cyano, which are useful as cardiotonics (II, Q min is hydrogen) and/or intermediates (II, Q min is cyano or hydrogen). Processes for preparing the compounds of Formulas I and II are shown.